Why do anticholinergics cause hypotension

Central inhibition leads to an agitated hyperactive delirium - typically including confusion, restlessness and picking at imaginary objects - which characterises this toxidrome. Peripheral inhibition is variable - but the symptoms may include: hot, dry skin, flushed appearance, mydriasis, tachycardia, decreased bowel sounds and urinary retention. Polypharmacy overdoses may make the anticholinergic toxidrome less apparent. If anticholinergic syndrome is suspected please seek senior advice and discuss with toxicologist.

The characteristic feature of toxicity at central receptors is agitated delirium. This may include:. The features of toxicity at peripheral and central receptors can be remembered using the following mnemonic.

Accidental ingestion: Parent information sheet from Victorian Poisons Information centre on the prevention of poisoning. Intentional self-harm: Referral to local mental health services e. Orygen Youth Health: All patients with intentional ingestions, should be admitted under the adolescent or psychiatric units.

The Royal Children's Hospital Melbourne. Amitriptyline showed evidence of anticholinergic effects in that salivary production fell to a level significantly lower than that of the mianserin- or placebo-treated subjects. The distance of the near point tended to increase during amitriptyline treatment. Compared with placebo, amitriptyline also significantly reduced pupil diameter on some occasions. This is because seniors may be more likely to experience unwanted side effects than younger people.

Even when using this drug properly, side effects can happen. The possible side effects of anticholinergics depend on the specific drug and dosage you take. Long-term use of anticholinergics, as well as use of these drugs in older people , has been linked with an increased risk of dementia.

Anticholinergics can be used to treat a variety of conditions. If you think one of these drugs could help you, talk to your doctor. Your doctor can determine if treatment with an anticholinergic would be a good option for you. They can also answer any questions you have about:. Anticholinergic drugs block the action of a neurotransmitter called acetylcholine. This inhibits nerve impulses responsible for involuntary muscle movements and various bodily functions.

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